Which statement best describes the main advantage of a computerized provider order entry (CPOE) system?

The main advantage of a computerized provider order entry (CPOE) system lies in its ability to enhance patient safety by significantly reducing errors associated with medication orders and other provider instructions. CPOE systems minimize the chances of misinterpretation that can occur with handwritten orders, thus decreasing the likelihood of medication errors related to illegible handwriting or miscommunication. By standardizing the ordering process and integrating clinical decision support, CPOE can alert providers to potential drug interactions, allergies, or contraindications, which further promotes safe patient care.

In contrast, while it is true that CPOE may reduce writing time for orders and could potentially streamline communication between nurses and providers, these factors are not the primary benefit or the main focus of its design. Additionally, the statement regarding nurses not acknowledging CPOE orders does not reflect a true advantage but rather highlights a possible concern in the workflow. Therefore, the enhancement of patient safety through error reduction is the most compelling advantage of CPOE systems.